The Jiggins Lab Webpage
Daniel Fabian
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Research Interests |
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I am interested in the genetic basis of traits and the selective mechanisms causing adaptation, particularly in the context of immunity and life history. To study these topics I am using the fruit fly Drosophila melanogaster as a model organism, which is a powerful system due to its well-described genome and the availability of functional genetic tools.
In my current work, I am combining next-generation sequencing with population genetics, statistical methods and functional genetic validation to understand how polymorphisms, genes and molecular pathways influence resistance to viruses in Drosophila species. Due to the strong conservation of the innate immune system across multiple taxa, studying the molecular underpinnings of pathogen resistance in insects could help to identify general mechanisms of immunity. |
Career History |
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2014 - present: Post-Doctoral researcher, Department of Genetics, University of Cambridge
2010 - 2014: PhD, Institute of Population Genetics, University of Veterinary Medicine Vienna, Advisors: T. Flatt, C. Schlötterer 2009 - 2010: Diploma work, Department of Genetics, University of Cambridge, Advisor: F. Jiggins 2006 - 2010: Diploma in Biotechnology & Biomedicine, University of Applied Sciences Vienna |
Publications |
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Fabian DK, Lack JB, Mathur V, Schlötterer C, Schmidt PS, Pool JE, Flatt T (2014) Clinal life history variation among populations of Drosophila melanogaster from sub-Saharan Africa. (submitted)
Magwire MM, Fabian DK, Schweyen H, Cao C, Longdon B, Bayer F and Jiggins FM (2012) Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila. PLoS Genetics 8: e1003057 Fabian DK, Kapun M, Nolte V, Kofler R, Schmidt PS, Schlötterer C, Flatt T (2012) Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. Molecular Ecology 21: 4748- 4769 Fabian D, Flatt T (2012) Life History Evolution. Nature Education Knowledge 3: 24 Longdon B, Fabian DK, Hurst GDD and Jiggins FM (2011) Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection. BMC Microbiology 12: S8 Fabian D, Flatt T (2011) The evolution of aging. Nature Education Knowledge 3: 9 |