The Jiggins Lab Webpage



Longdon B, Day JP, Schulz N, Leftwich PT, de Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, SmithSCL , McGonigle JE, Houslay TM, Wright LI, Livraghi L, Evans LC, Friend LA, Chapman T, Vontas J, Kambouraki N, Jiggins FM 2017 Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B. In Press


Juneja, P, Quinn, A, Jiggins, FM 2016 Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. BMC Genomics. 17:981 [PDF]

Cogni, R, Cao, C, Day, JP, Bridson, C, Jiggins, FM 2016 The genetic architecture of resistance to virus infection in Drosophila. Molecular Ecology. 25: 52285241 [PDF]

Petit, M, Mongellia, V, Frangeula, L, Blanca, H, Jiggins, FM and Saleh, MC 2016 piRNA pathway is not required for antiviral defense in Drosophila melanogaster. Proc. Nat. Acad. Sci. USA [PDF]

Martinez, J, Cogni, R, Cao, C, Smith, S, Illingworth, CJR, Jiggins, FM 2016 Addicted? Reduced host resistance in populations with defensive symbionts. Proc. R. Soc. B. 283: 20160778. [PDF]

Rainey, SM, Martinez, J, McFarlane, M, Juneja, P, Sarkies, P, Lulla, A, Schnettler, A, Varjak, M, Merits, A, Miska, EA, Jiggins, FM, Kohl, A 2016 Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways. PLoS Pathogens [PDF]

Hoy, MA, Waterhouse, RM, Wu, K, Estep, AS, Ioannidis, P, Palmer, WJ, Pomerantz, AF, Simo, FA, Thomas, J, Jiggins, FM, Murphy, TD, Pritham, EJ, Robertson, HM, Zdobnov, EM, Gibbs, RA and Richards S 2016 Genome sequencing of the phytoseiid predatory mite Metaseiulus occidentalis reveals completely atomised Hox genes and super-dynamic intron evolution. Genome Biol. Evol. 8 : 1762-1775. [PDF]

Palmer, WJ, Duarte, A, Schrader, M, Day, JP, Kilner, R, Jiggins, FM 2016 A gene associated with social immunity in the burying beetle Nicrophorus vespilloides. Proc. R. Soc. B. 283: 20152733 [PDF]

Cao, C, Magwire, MM, Bayer, F and Jiggins, FM 2015 A Polymorphism in the processing body component Ge-1 Controls Resistance to a naturally occurring Rhabdovirus in Drosophila. PLoS Pathogens. [PDF] Access the recommendation on F1000Prime

Martin, SH, Mst, M, Palmer, WJ, Salazar, C, McMillan, WO, Jiggins, FM and Jiggins, CD 2016 Natural Selection and Genetic Diversity in the Butterfly Heliconius Melpomene. Genetics. 203, 525541. [PDF]

Cattel, J, Martinez, J, Jiggins, FM, Mouton, L, Gibert, P 2016 Wolbachia-mediated protection against viruses in the invasive pest Drosophila suzukii. Insect Molecular Biology. 25: 595603.[PDF]

Cattel, J, Kaur, R, Gibert, P, Martinez, J, Fraimout, A, Jiggins, FM, Andrieux, T, Siozios, S, Anfora, G, Miller, W, Rota-Stabelli, O, Mouton, L 2016 Wolbachia in European Populations of the Invasive Pest Drosophila suzukii: Regional Variation in Infection Frequencies. PLoS One. 11: e0147766 [PDF]

Jiggins, FM 2016 Open questions: How does Wolbachia do what it does? BMC Biology. 14:92 [PDF]


Longdon, B, Murray, G, Palmer, WJ, Day, JP, Parker, D, Welch, JJ, Obbard, DJ, Jiggins, FM 2015 The evolution, diversity and host associations of rhabdoviruses. Virus Evolution. 1: vev014. [PDF]

Martinez, J, Ok, S, Smith, S, Snoeck, K, Day, JP and Jiggins, FM 2015 Should Symbionts Be Nice or Selfish? Antiviral Effects of Wolbachia Are Costly but Reproductive Parasitism Is Not. PLoS Pathogens. 11: e1005021. [PDF]

Palmer, WJ and Jiggins, FM 2015 Comparative genomics reveals the origins and diversity of arthropod immune systems. Molecular Biology and Evolution. 32:21112129 [PDF]

Juneja, P, Ariani, CV, Ho, YS, Osei-Poku, J, Palmer, WJ, Pain, A and Jiggins, FM 2015 Exome and Transcriptome Sequencing of Aedes aegypti Identifies a Locus that Confers Resistance to Brugia malayi and Alters the Immune Response. PLoS Pathogens. 11: e1004765. [PDF]

Longdon, B, Hadfield, JD, Day, JP, Smith, SCL, McGonigle, JE, Cogni, R, Cao, C and Jiggins, FM 2015 The causes and consequences of changes in virulence following pathogen host shifts. PLoS Pathogens. 11: e1004728. [PDF]

Ariani, CV, Juneja, P, Smith, S, Tinsley, MC and, Jiggins, FM 2015 Vector competence of Aedes aegypti mosquitoes for filarial nematodes is affected by age and nutrient limitation. Experimental Gerontology. 61:47-53. [PDF]

Ariani, CV, Smith, S, Osei-Poku, J, Short, K, Juneja, P, and, Jiggins, FM 2015 Environmental and genetic factors determine whether the mosquito Aedes aegypti lays eggs without a blood meal. American Journal of Hygiene and Tropical Medicine. 92: 715-721. [PDF]

Ahmed, MZ, Li, SJ, Xue, X, Yin, XJ, Ren, SX, Jiggins, FM, Greeff, JM and Qiu, BL 2015 The Intracellular Bacterium Wolbachia Uses Parasitoid Wasps as Phoretic Vectors for Efficient Horizontal Transmission. PLoS Pathogens. 10: e1004672 [PDF]


Longdon, B, Brockhurst, MA, Russell, CA, Welch, JJ and Jiggins, FM 2014 The Evolution and Genetics of Virus Host Shifts. PLoS Pathogens. 10: e1004395 [PDF]

Martinez, J, Longdon, B, Bauer, S, Chan, Y-S, Miller, WJ, Bourtzis, K, Teixeira, L and Jiggins, FM 2014 Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains. PLoS Pathogens. 9: e1004369 [PDF]

Quinn, A, Juneja, P and Jiggins, FM 2014 Estimates of allele-specific expression in Drosophila with a single genome sequence and RNA-seq data. Bioinformatics. 30: 2603-2610. [PDF] [PDF supp]

Wilfert, L and Jiggins, FM 2014 Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Molecular Ecology. 23, 20932104 [PDF]

Juneja, P, Osei-Poku, J, Ho, YS, Ariani, CV, Palmer, WJ, Pain, A and Jiggins, FM 2014 Assembly of the Genome of the Disease Vector Aedes aegypti onto a Genetic Linkage Map Allows Mapping of Genes Affecting Disease Transmission. PLoS Neglected Tropical Diseases. 8: e2652 [PDF]

The Strigamia Genome Consortium 2014 Prototypical Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima. PLoS Biology. 12: e1002005 [PDF]


Wilfert, L and Jiggins, FM 2013 The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in Drosophila. Evolution. 67: 761-773. [PDF]

Chrostek, E, Marialva, MSP, Esteves, SS, Weinert, LA, Martinez, J, Jiggins, FM and Teixeira, L 2013 Wolbachia Variants Induce Differential Protection to Viruses in Drosophila melanogaster: A Phenotypic and Phylogenomic Analysis. PLoS Genetics. 9:e1003896 [PDF]

Longdon B, Cao, C, Martinez, J and Jiggins FM 2013 Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster. PLoS One. 8: e73833 [PDF]


Magwire, MM, Fabian, DK, Schweyen, H, Cao, C, Longdon B, Bayer, F and Jiggins, FM 2012 Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila. PLoS Genetics. 8: e1003057. [PDF] [Data]

Osei-Poku, J, Mbogo, CM, Palmer, WJ and Jiggins, FM 2012 Deep sequencing reveals extensive variation in the gut microbiota of wild mosquitoes from Kenya. Molecular Ecology. 21, 5138-5150. [PDF]

Osei-Poku J, Han C, Mbogo CM and Jiggins FM 2012 Identification of Wolbachia Strains in Mosquito Disease Vectors. PLoS One. 7: e49922. [PDF]

Longdon B and Jiggins FM 2012 Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone? Proceedings of the Royal Society B. 279: 3889-3898. [PDF]

Obbard, DJ, Maclennan, J, Kim, KW, Rambaut, A, O'Grady, PM and Jiggins, FM 2012 Estimating divergence dates and substitution rates in the Drosophila phylogeny. Molecular Biology and Evolution. 29: 3459-3473. [PDF]

Carpenter, JA, Hadfield, JD, Bangham, J and Jiggins, FM 2012 Specific interactions between host and parasite genotypes do not act as a constraint on the evolution of antiviral resistance in Drosophila. Evolution. 66: 1114-1125. [PDF]

Longdon B, Fabian DK, Hurst GDD and Jiggins FM 2012 Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection. BMC Microbiology. 12(Suppl 1):S8 [PDF]

Longdon B, Wilfert L and Jiggins FM 2012 The Sigma viruses of Drosophila. In: Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Cytopathology and Control, edited by Ralf Dietzgen and Ivan Kuzmin. Caister Academic Press. [PDF]

Richardson, MF, Weinert, LA, Welch, JJ, Linheiro, RS, Magwire, MM, Jiggins, FM and Bergman, CM 2012 Population genomics of the Wolbachia endosymbiont in Drosophila melanogaster. PLoS Genetics. 8: e1003129. [PDF]

The Heliconius Genome Consortium 2012 Butterfly genome reveals promiscuous exchange of mimicry adaptations among species. Nature. 487:94-98 [PDF]


Longdon, B, Hadfield, JD, Webster, CL, Obbard, DJ and Jiggins, FM 2011 Host phylogeny determines viral persistence and replication in novel hosts. PLoS Pathogens. e1002260. [PDF]

Magwire, MM, Bayer, F, Webster, CL, Cao, C and Jiggins, FM 2011 Successive Increases in the Resistance of Drosophila to Viral Infection through a Transposon Insertion Followed by a Duplication. PLoS Genetics. 7: e1002337. [PDF]

Longdon, B, Wilfert, L, Osei-Poku, J, Cagney, H, Obbard, DJ and Jiggins, FM 2011 Host-switching by a vertically-transmitted rhabdovirus in Drosophila. Biology Letters. 7: 747-750 [PDF]

Wilfert, L, Longdon, B, Ferreira, AGA, Bayer, F and Jiggins, FM 2011 Trypanosomatids are common and diverse parasites of Drosophila. Parasitology. 138, 858-865. [PDF]

Longdon, B, Wilfert, L, Obbard, DJ and Jiggins, FM 2011 Rhabdoviruses in Two Species of Drosophila: Vertical Transmission and a Recent Sweep. Genetics. 188: 141-150. [PDF]

Wells, PM, Baverstock, J, Majerus, MEN, Jiggins, FM, Roy, HE,and Pell, JK 2011 The effect of the coccinellid Harmonia axyridis (Coleoptera: Coccinellidae) on transmission of the fungal pathogen Pandora neoaphidis (Entomophthorales: Entomophthoraceae). Eur. J. Entomol. 108: 87-90 [PDF]

Michie, LJ, Masson, A, Ware, R and Jiggins, FM 2011 Seasonal phenotypic plasticity: wild ladybirds are darker at cold temperatures. Evolutionary Ecology. 25: 1259-1268. [PDF]

Jiggins, FM and Hurst, GDD 2011 Rapid insect evolution by symbiont transfer. Science. 332: 185-186 [PDF]


Obbard, DJ, Jiggins, FM, Bradshaw, NJ and Little, TJ 2010 Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Molecular Biology and Evolution. 28: 1043-1056 [PDF]

Michie, LJ, Mallard, F, Majerus MEN and Jiggins FM 2010 Melanic through nature or nurture: genetic polymorphism and phenotypic plasticity in Harmonia axyridis. Journal of Evolutionary Biology. 23: 1699-1707 [PDF]

Longdon, B and Jiggins, FM 2010 Paternally transmitted parasites. Current Biology. 20: R695-R696 [PDF]

Wilfert, L and Jiggins, FM 2010 Disease association mapping in Drosophila can be replicated in the wild. Biology Letters. 6: 666-668. [PDF]

Wilfert, L and Jiggins, FM 2010 Host-parasite coevolution: genetic variation in a virus population and the interaction with a host gene. Journal of Evolutionary Biology. 23: 1447-1455 [PDF]

Rhule, EL, Majerus, MEN, Jiggins, FM and Ware, RL 2010 Potential role of the sexually transmitted mite Coccipolipus hippodamiae in controlling populations of the invasive ladybird Harmonia axyridis. Biological Control. 53: 243-247 [PDF]


Carpenter, JA, Keegan, L, Wilfert, L, O'Connell, MA and Jiggins, FM 2009 Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). BMC Genetics. 10, 75. [PDF]

Obbard, DJ, Welch, JJ, Kim, K-W, and Jiggins, FM 2009 Quantifying Adaptive Evolution in the Drosophila Immune System. PLoS Genetics. 5: e1000698. [PDF]

Longdon, B, Obbard, DJ & Jiggins, FM 2009 Sigma viruses from three species of Drosophila form a major new clade in the rhabdovirus phylogeny. Proceedings of the Royal Society B. 277: 35-44 [PDF]

Carpenter, J., Hutter, S., Baines, J. F., Roller, J., Saminadin-Peter, S. S., Parsch, J. & Jiggins, F. M. 2009 The Transcriptional Response of Drosophila melanogaster to Infection with the Sigma Virus (Rhabdoviridae). PLoS ONE 4, e6838. [PDF]

Weinert, LA, Welch, JJ, & Jiggins, FM 2009 Conjugation genes are common throughout the genus Rickettsia and are transmitted horizontally. Proceedings of the Royal Society B. 276: 3601-3610 [PDF]

Weinert, LA, Werren, JH, Aebi, A, Stone, GN & Jiggins, FM 2009 Evolution and diversity of Rickettsia bacteria. BMC Biology 7: 6 [PDF]

Obbard, D.J. Gordon, K.H.J., Buck, A.H., and Jiggins, F.M. 2009 The evolution of RNAi as a defence against viruses and transposable elements. Philosophical Transactions of the Royal Society. 364: 99-115 [PDF]

Before 2009

Bangham, J., Knott, S.A. Kim, K.-W., Young R.S., and Jiggins, F.M. 2008 Genetic variation affecting host-parasite interactions: major-effect quantitative trait loci affect the transmission of sigma virus in Drosophila melanogaster. Molecular Ecology. 17: 3800-3807.[PDF]

Bangham J, Kim KW, Webster C, Jiggins FM 2008 Genetic variation affecting host-parasite interactions: different genes affect different aspects of sigma virus replication and transmission in Drosophila melanogaster. Genetics. 178:2191-2199. [PDF]

Weinert LA, Tinsley MC, Temperley M, Jiggins FM 2008 Are we underestimating the diversity and incidence of insect bacterial symbionts? A case study in ladybird beetles. Biology Letters. 3: 678-681 [PDF]

Obbard, DJ, Callister, DM, Jiggins, FM, Soares, DC, Yan, G, Little, T J 2008 The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evolutionary Biology 8, 274. [PDF]

Bangham J, Obbard DJ, Kim KW, Haddrill PR, Jiggins FM 2007 The age and evolution of an antiviral resistance mutation in Drosophila melanogaster. Proceedings of the Royal Society B. 274: 2027-2034 [PDF]

Jiggins FM, Kim KW, 2007 A screen for immunity genes evolving under positive selection in Drosophila. Journal of Evolutionary Biology. 20: 965-970 [PDF]

Obbard DJ, Linton YM, Jiggins FM, Yan G, Little TJ 2007 Population genetics of Plasmodium resistance genes in Anopheles gambiae: no evidence for strong selection. Molecular Ecology. 16: 3497-3510 [PDF]

Carpenter, J, Obbard, DJ, Maside, X, and Jiggins, FM 2007 The recent spread of a vertically transmitted virus through populations of Drosophila melanogaster. Molecular Ecology. 16: 3947-3954 [PDF]

Bangham, J, Jiggins, FM, and Lemaitre, B 2006 Insect Immunity: The Post-Genomic Era. Immunity 25: 1-5. [PDF]

Jiggins, FM, and Kim KW 2006 Contrasting evolutionary patterns in Drosophila immune receptors. J. Mol. Evol. 63: 769-780. [PDF]

Obbard, DJ, Jiggins, FM, Halligan, DL and Little TJ 2006 Natural Selection Drives Extremely Rapid Evolution in Antiviral RNAi Genes. Current Biology 16: 580-585. [PDF]

Jiggins, FM 2006 Adaptive evolution and recombination of Rickettsia antigens. J. Mol. Evol. 62: 99-110 [PDF]

Tinsley, MT, Blanford, S and Jiggins, FM 2006 Genetic variation in the Drosophila melanogaster immune response. Parasitology. 132: 767-773 [PDF]

Jiggins, FM and Kim KW 2005 The evolution of antifungal peptides in Drosophila. Genetics. 171: 1847-1859 [PDF]

Jiggins, FM and Tinsley, MT 2005 An ancient mitochondrial polymorphism linked to a sex ratio distorting bacterium. Genetics. 171: 1115-1124 [PDF]

Hurst, GDD and Jiggins, FM 2005 Problems with mitochondrial DNA as a marker in population, phylogeographic and phylogenetic studies: the effects of inherited symbionts. Proc. R. Soc. Lond. B 272: 1525-1534. [PDF]

Jiggins, FM 2003 Male-killing Wolbachia and mitochondrial DNA: selective sweeps, hybrid introgression and parasite population dynamics. Genetics 164: 5-12. [PDF]

Jiggins, FM and Hurst, GDD 2003 The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins. J. Mol. Evol. 57: 598-605. [PDF]

Hurst, G. D. D., F. M. Jiggins and M. E. N. Majerus, 2003 Inherited microorganisms that selectively kill male hosts: the hidden players of insect evolution? in Insect symbiosis, edited by K. Bourtzis and T. A. Miller. RC Press, Boca Raton. [PDF]

Keeling, M. J., F. M. Jiggins and J. M. READ, 2003 The invasion and coexistence of competing Wolbachia strains. Heredity 91: 382-388. [PDF]

Dobson, S. L., C. W. Fox and F. M. Jiggins , 2002 The effect of Wolbachia-induced cytoplasmic incompatibility on host population size in natural and manipulated systems. Proc. R. Soc. Lond. B 269: 437-445. [PDF]

Jiggins , F. M., J. K. Bentley, M. E. N. Majerus and G. D. D. Hurst, 2002 Recent changes in phenotype and patterns of host specialisation in Wolbachia bacteria. Molecular Ecology 11: 1275-1283. [PDF]

Jiggins , F. M., 2002 The rate of recombination in Wolbachia bacteria. Mol. Biol. Evol. 19: 1640-1643. [PDF]

Jiggins , F. M., J. P. Randerson, G. D. D. Hurst and M. E. N. Majerus, 2002 How can sex ratio distorters reach extreme prevalences? A natural population in which male-killing Wolbachia have near-perfect vertical transmission efficiency and are not suppressed. Evolution 56: 2290-2295. [PDF]

Jiggins , F. M., G. D. D. Hurst and Z. Yang, 2002 Host-symbiont conflicts: positive selection on the outer membrane protein of parasitic but not mutualistic Rickettsiaceae. Mol. Biol. Evol. 19: 1341-1349. [PDF]

Hurst, G. D. D., F. M. Jiggins and A. Pomiankowski, 2002 Which way to manipulate reproduction? Wolbachia that cause cytoplasmic incompatibility are easily invaded by sex ratio distorting mutants. Am. Nat. 160: 360-373. [PDF]

Jiggins, F. M., Bentley, M. E. N. Majerus and G. D. D. Hurst, 2001 How many species are infected with Wolbachia? Cryptic sex ratio distorters revealed to be common by intensive sampling. Proc. R. Soc. Lond. B 268: 1123-1126. [PDF]

Jiggins , F. M., G. D. D. Hurst, J. H. G. V. d. Schulenburg and M. E. N. Majerus, 2001 Two male-killing Wolbachia strains coexist within a population of the butterfly Acraea encedon. Heredity 86: 161-166. [PDF]

Jiggins , F. M., J. H. G. V. d. Schulenburg, G. D. D. Hurst and M. E. N. Majerus, 2001 Recombination confounds interpretations of Wolbachia evolution. Proc. R. Soc. Lond. B 268: 1423-1427. [PDF]

Hurst, G. D. D., F. M. Jiggins and S. J. W. Robinson, 2001 What causes inefficient transmission of male-killing Wolbachia in Drosophila? Heredity 87: 220-226. [PDF]

Jiggins , F. M., G. D. D. Hurst, C. E. Dolman and M. E. N. Majerus, 2000 High prevalence male-killing Wolbachia in the butterfly Acraea encedana. J. Evol. Biol. 13: 495-501. [PDF]

Jiggins , F. M., G. D. D. Hurst and M. E. N. Majerus, 2000 Sex ratio distorting Wolbachia cause sex role reversal in their butterfly hosts. Proc. R. Soc. Lond. B 267: 69-73. [PDF]

Jiggins , F. M., G. D. D. Hurst, C. D. Jiggins, J. H. G. V. d. Schulenburg and M. E. N. Majerus, 2000 The butterfly Danaus chrysippus is host to a male-killing Spiroplasma bacterium. Parasitology 120: 439-446. [PDF]

Randerson, J. P., F. M. Jiggins and L. D. Hurst, 2000 Male-killing can select for male mate choice: a novel solution to the paradox of the lek. Proc. R. Soc. Lond. B 267: 867-874. [PDF]

Hurst, G. D. D., and F. M. Jiggins, 2000 Male-killing bacteria in insects: mechanisms, incidence, and implications. Emerging Infect. Dis. 6: 329-336. [PDF]

Jiggins, F. M., G. D. D. Hurst and M. E. N. Majerus, 1999 How common are meiotically driving sex chromosomes in insects? Am. Nat. 154: 481-483. [PDF]

Hurst, G. D. D., F. M. Jiggins, J. H. G. Schulenburg, D. Bertrand, S. A. West et al., 1999 Male-killing Wolbachia in two species of insect. Proc. R. Soc. Lond. B 266: 735-740. [PDF]

Jiggins, F. M., G. D. D. Hurst and M. E. N. Majerus, 1998 Sex ratio distortion in Acraea encedon (Lepidoptera: Nymphalidae) is caused by a male-killing bacterium. Heredity 81: 87-91. [PDF]