The Jiggins Lab Webpage

Research Interests

Education and Employment

2008-2012: Post Doc, University of Glasgow, Department of Biochemistry

2004-2008: Post Doc, University of Glasgow, Department of Genetics

2001-2004: PhD , University of Glasgow, Department of Genetics

2000-2001: MRes, University of Glasgow

1998-2000: BSc, University of East Anglia, Biochemistry

Publications

Martinez J, Bruner-Montero G, Arunkumar R, Smith SCL, Day JP, Longdon B, Jiggins FM. Virus evolution in Wolbachia-infected Drosophila. Proc Biol Sci. 2019 Nov 6;286(1914)

Leitao AB, Bian X, Day JP, Pitton S, Demir E, Jiggins FM. Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids. PLoS Pathog. 2019 Oct 7;15(10)

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.

Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS. A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling. Transl Psychiatry. 2019 May 10;9(1):141 Duxbury EM, Day JP, Maria Vespasiani D, Thüringer Y, Tolosana I, Smith SC, Tagliaferri L, Kamacioglu A, Lindsley I, Love L, Unckless RL, Jiggins FM, Longdon B. Host-pathogen coevolution increases genetic variation in susceptibility to infection. Elife. 2019 Apr 30;8

Alves JM, Carneiro M, Cheng JY, Lemos de Matos A, Rahman MM, Loog L, Campos PF, Wales N, Eriksson A, Manica A, Strive T, Graham SC, Afonso S, Bell DJ, Belmont L, Day JP, Fuller SJ, Marchandeau S, Palmer WJ, Queney G, Surridge AK, Vieira FG, McFadden G, Nielsen R, Gilbert MTP, Esteves PJ, Ferrand N, Jiggins FM. Parallel adaptation of rabbit populations to myxoma virus. Science. 2019 Mar 22;363(6433):1319-1326.

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS. RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Sci OA. 2018 Jul 2;4(7)

Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM. Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathog. 2018 Apr 12;14(4)

McGonigle JE, Leitão AB, Ommeslag S, Smith S, Day JP, Jiggins FM. Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species. PLoS Pathog. 2017 Oct 19;13(10)

Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS. FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Mol Psychiatry. 2017 Jul 20

Martinez J, Tolosana I, Ok S, Smith S, Snoeck K, Day JP, Jiggins FM. Symbiont strain is the main determinant of variation in Wolbachia-mediated protection against viruses across Drosophila species. Mol Ecol. 2017 Aug;26(15):4072-4084

Crawford JE, Alves JM, Palmer WJ, Day JP, Sylla M, Ramasamy R, Surendran SN, Black WC 4th, Pain A, Jiggins FM. Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector. BMC Biol. 2017 Feb 28;15(1)

Longdon B, Day JP, Schulz N, Leftwich PT, de Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SC, McGonigle JE, Houslay TM, Wright LI, Livraghi L, Evans LC, Friend LA, Chapman T, Vontas J, Kambouraki N, Jiggins FM. Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proc Biol Sci. 2017 Jan 25;284(1847)

Cameron RT, Whiteley E, Day JP, Parachikova AI, Baillie GS. Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity. FEBS Open Bio. 2016 Dec 5;7(1):64-73

Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T. Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. Elife. 2016 Aug 23;5

Tankou S, Ishii K, Elliott C, Yalla KC, Day JP, Furukori K, Kubo KI, Brandon NJ, Tang Q, Hayward G, Nakajima K, Houslay MD, Kamiya A, Baillie G, Ishizuka K, Sawa A. SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Mol Neuropsychiatry. 2016 May;2(1):20-27

Cogni R, Cao C, Day JP, Bridson C, Jiggins FM. The genetic architecture of resistance to virus infection in Drosophila. Mol Ecol. 2016 Oct;25(20):5228-5241

Palmer WJ, Duarte A, Schrader M, Day JP, Kilner R, Jiggins FM. A gene associated with social immunity in the burying beetle Nicrophorus vespilloides. Proc Biol Sci. 2016 Jan 27;283(1823)

Martinez J, Ok S, Smith S, Snoeck K, Day JP, Jiggins FM. Should Symbionts Be Nice or Selfish? Antiviral Effects of Wolbachia Are Costly but Reproductive Parasitism Is Not. PLoS Pathog. 2015 Jul 1;11(7)

Longdon B, Hadfield JD, Day JP, Smith SC, McGonigle JE, Cogni R, Cao C, Jiggins FM. The causes and consequences of changes in virulence following pathogen host shifts. PLoS Pathog. 2015 Mar 16;11(3)

Bolger GB, Dunlop AJ, Meng D, Day JP, Klussmann E, Baillie GS, Adams DR, Houslay MD. Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cell Signal. 2015 Apr;27(4):756-69

Longdon B, Murray GG, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM. The evolution, diversity, and host associations of rhabdoviruses. Virus Evol. 2015 Nov 13;1(1)

Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA. The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat Neurosci. 2015 Aug;18(8):1094-100

Kaname T, Ki CS, Niikawa N, Baillie GS, Day JP, Yamamura K, Ohta T, Nishimura G, Mastuura N, Kim OH, Sohn YB, Kim HW, Cho SY, Ko AR, Lee JY, Kim HW, Ryu SH, Rhee H, Yang KS, Joo K, Lee J, Kim CH, Cho KH, Kim D, Yanagi K, Naritomi K, Yoshiura K, Kondoh T, Nii E, Tonoki H, Houslay MD, Jin DK. Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis. Cell Signal. 2014 Nov;26(11):2446-59

Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, Houslay MD, Baillie GS. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16)

Cameron RT, Coleman RG, Day JP, Yalla KC, Houslay MD, Adams DR, Shoichet BK, Baillie GS. Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochem Pharmacol. 2013 May 1;85(9):1297-305

Scheunemann L, Jost E, Richlitzki A, Day JP, Sebastian S, Thum AS, Efetova M, Davies SA, Schwärzel M. (2012) Consolidated and Labile Odor Memory Are Separately Encoded within the Drosophila Brain. J Neurosci. Nov 28;32(48):17163-71

Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T (2012), Gravin orchestrates PKA and Beta2-adrenergic receptor signaling critical for synaptic plasticity and memory, J Neurosci. 32(50):18137-49

Brown KM, Lee LC, Findlay JE, Day JP, Baillie GS. (2012) Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. FEBS Lett. 586(11):1631-7

Day, J.P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R.W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E.K., et al. (2011). Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem 54, 3331-3347.

Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F., Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D., and Baillie, G.S. (2011). Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the beta-agonist induced hypertrophic response in cardiac myocytes. J Mol Cell Cardiol 50, 872-883.

Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G., Houslay, M.D., and Baillie, G.S. (2011). beta-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol 31, 1066-1075.

Christian, F., Anthony, D.F., Vadrevu, S., Riddell, T., Day, J.P., McLeod, R., Adams, D.R., Baillie, G.S., and Houslay, M.D. (2010). p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cell Signal 22, 1576-1596.

Kelly, M.P., Logue, S.F., Brennan, J., Day, J.P., Lakkaraju, S., Jiang, L., Zhong, X., Tam, M., Sukoff Rizzo, S.J., Platt, B.J., et al. (2010). Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A 107, 8457-8462.

Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffrey, E., Hay, R.T., Adams, D.R., et al. (2010). Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J 428, 55-65.

Day, J. P., Cleghon, V., Houslay, M. D., and Davies, S. A. (2008). Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochem J 414, 363-374.

Day, J. P., Wan, S., Allan, A. K., Kean, L., Davies, S. A., Gray, J. V., and Dow, J. A. (2008). Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. J Cell Sci 121, 2612-2619.

Evans, J. M., Day, J. P., Cabrero, P., Dow, J. A., and Davies, S. A. (2008). A new role for a classical gene: white transports cyclic GMP. J Exp Biol 211, 890-899.

Davies, S. A., and Day, J. P. (2007). Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics, In Cyclic Nucleotide Phosphodiesterases in Health and Disease, J. A. F. Beavo, S. H. Houslay, M. D., ed. (Boca Raton: CRC Press), pp. 301-320.

Day, J. P., Houslay, M. D., and Davies, S. A. (2006). A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochem J 393, 481-488.

Weller, G.R., Kysela, B., Roy, R., Tonkin, L.M., Scanlan, E., Della, M., Devine, S.K., Day, J.P., Wilkinson, A., d'Adda di Fagagna, F., et al. (2002). Identification of a DNA nonhomologous end-joining complex in bacteria. Science 297, 1686-1689.